簡(jiǎn)要描述：細(xì)胞死亡后會(huì)釋放一類特殊的蛋白質(zhì) Alarmin（暫譯為警報(bào)素），通過(guò)檢測(cè) Alarmin 可識(shí)別組織創(chuàng)傷。然而在抗病毒免疫系統(tǒng)中，Alarmin 所起的作用不是很明確。最近瑞士日內(nèi)瓦大學(xué)和德國(guó)柏林夏里特醫(yī)科大學(xué)研究人員發(fā)現(xiàn)在脾臟和淋巴結(jié)中病毒的復(fù)制可導(dǎo)致受感染的細(xì)胞死亡。
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| 品牌 | 其他品牌 | 供貨周期 | 一個(gè)月 |
|---|
IL-33（釋放于壞死細(xì)胞）動(dòng)員殺傷性Ｔ細(xì)胞應(yīng)對(duì)病毒感染
◆原理
細(xì)胞死亡后會(huì)釋放一類特殊的蛋白質(zhì) Alarmin（暫譯為警報(bào)素），通過(guò)檢測(cè) Alarmin 可識(shí)別組織創(chuàng)傷。然而在抗病毒免疫系統(tǒng)中，Alarmin 所起的作用不是很明確。最近瑞士日內(nèi)瓦大學(xué)和德國(guó)柏林夏里特醫(yī)科大學(xué)研究人員發(fā)現(xiàn)在脾臟和淋巴結(jié)中病毒的復(fù)制可導(dǎo)致受感染的細(xì)胞死亡。這些壞死的細(xì)胞可釋放出 Alarmin，其中主要的是白介素-33（IL-33），它可通過(guò) ST2 受體激活 CD8+ T（CTLs）細(xì)胞，對(duì)病毒感染作出反應(yīng)。研究發(fā)現(xiàn)缺乏 IL-33 的小鼠，CTL 對(duì)病毒感染的免疫反應(yīng)也較低。此項(xiàng)研究具有里程碑意義，因?yàn)樘岢隽艘粋€(gè)新的免疫機(jī)制：壞死細(xì)胞會(huì)釋放出 Alarmin 動(dòng)員殺傷性Ｔ細(xì)胞應(yīng)對(duì)感染，在未來(lái)對(duì)抗艾滋、丙型肝炎而開(kāi)發(fā)新的疫苗，對(duì)于癌癥治療有重要作用。
Enzo Life Sciences 提供大量細(xì)胞壞死研究用產(chǎn)品，先天性免疫適應(yīng)性免疫等。許多與 Alarmin IL-33 有關(guān)，供科研人員選擇。
◆優(yōu)點(diǎn)?特色
產(chǎn)品名稱 | 特點(diǎn) |
IL-33 (human), ELISA kit | Reliably measure as little as 1.7 pg/mL of IL-33 |
IL-33 (mouse) ELISA Kit | Reliably measure as little as 10pg/mL of IL-33 |
IL-33 soluble (human), detection set | Reliably measure as little as 5pg/mL of IL-33 |
GFP-Certified™ Apoptosis/Necrosis detection kit | Cell-based assay for microscopy and flow cytometry |
IL-33 (human), (recombinant) | ≥95% pure (SDS-PAGE) |
IL-33 (human), (recombinant) | ≥95% pure (SDS-PAGE), FLAG-tag |
IL-33 (human), (recombinant) | ≥95% pure (SDS-PAGE), His-tag |
Pro-IL-33 (human), (recombinant) | ≥90% pure (SDS-PAGE), His-tag |
IL-33 (human) (homeodomain-like helix-turn-helix), (recombinant) | Human IL-33 homeodomain, fused at C- terminus to His-tag, ≥95% pure (SDS-PAGE) |
IL-33 (mouse), (recombinant) | ≥95% pure (SDS-PAGE) |
IL-33 (mouse), (recombinant) | ≥95% pure (SDS-PAGE), His-tag |
IL-33 (rat), (recombinant) | ≥95% pure (SDS-PAGE) |
IL-33 (human), mAb | Suitable for ELISA, IHC, IP, WB (clone IL33305B) |
IL-33 (human), pAb | Suitable for ELISA, WB |
IL-33 (human), pAb | Suitable for ELISA, WB, Biotin conjugate |
IL-33 (mouse), pAb | Suitable for ELISA, WB |
IL-33, mAb | Recognizes human and mouse IL-33. ELISA, IP, WB.(clone IL33026B) |
IL-33, mAb | Recognizes human IL-33. Weakly cross-reacts with mouse IL-33. ELISA, WB. (clone IL33068A) |
IL-33, mAb | Recognizes human, mouse and rat pro-IL-33 (precursor) and mature IL-33. ELISA, IHC, IHC, IP, WB (clone Nessy-1) |
IL-33, mAb | Biotin-conjugate (clone Nessy-1) |
IL-33, mAb | Preservative free, (clone Nessy-1) |
IL-33, mAb | ICC, WB (clone Nessy-2) |
IL-33, pAb (AT110) | Recognizes human, mouse and rat pro-IL-33 and mature IL-33, ELISA, WB |
IL-33, pAb (AT110) | Biotin-conjugate |
ST2 (human), (recombinant) | ≥90% pure (SDS-PAGE) |
ST2 (human), mAb | ELISA, IHC, IHC, WB (clone ST33868) |
ST2 (human):Fc (human), (recombinant) | ≥90% pure (SDS-PAGE) |
ST2 (mouse):Fc (human), (recombinant) | ≥95% pure (SDS-PAGE) |
IL-1RAcP (human):Fc (human) (recombinant) | Forms heterodimer complex with ST2 to make the IL-33 receptor. ≥95% pure (SDS-PAGE) |
| 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | 產(chǎn)品規(guī)格 | 產(chǎn)品等級(jí) | 備注 |
| ADI-900-201 | IL-33 (human), ELISA kit IL-33 （人）, ELISA試劑盒 | 96wells等 | - | - |
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